Title of article :
Synthesis and anticancer evaluation of novel acenaphtho [1,2-e]-1,2,4- triazine derivatives
Author/Authors :
Adibi Sedeh ، Somayeh Department of Chemistry - Islamic Azad University, Khouzestan Science and Research Branch , Mohammadi ، Mohammad Kazem Department of Chemistry - Islamic Azad University, Ahvaz Branch , Fereidoonnezhad ، Masood Department of Medicinal Chemistry - Toxicology Research Center, School of Pharmacy - Ahvaz Jundishapur University of Medical Sciences , Javid ، Ali Department of chemistry - Islamic Azad University, Mashhad Branch
Abstract :
In this paper, we present the convenient syntheses of some new phenyl hydrazin derivatives 8 (a-h). For this purpose, condensation of thiosemicarbazide and acenaphtylene -9,10-quinone was performed to form acenaphtho[1,2-e]-1,2,4- triazine-9(8H)-thiones . Afterwards, the subsequent reaction with benzyl chloride derivatives was subjected to hydrazine and, then, the reaction was proceeded with different benzaldehyde derivatives to achieve 9-(phenyl imino hydrazin)- acenaphtho[1,2-e]-1,2,4-triazine derivatives (8a-h) in good yield. The cytotoxicity of the synthesized compounds was also studied against human cancer cell lines including breast (MCF-7), ovarian (SKOV3) and lung (A549) cell lines. Among them 8b, 8c and 8h showed moderate to good activity.
Keywords :
Synthesis , triazines , benzyl thio , imino hydrazine , Aldehydes , Anticancer
Journal title :
Eurasian Chemical Communications
Journal title :
Eurasian Chemical Communications
