Multi-component synthesis of spiro[indoline-3,4’-pyrrolo[3,4-c]pyrazoles] using Zn(BDC) metal-organic frameworks as a green and efficient catalyst

In this research, a series of spiro compounds was efficiently synthesized via onepot multi component reactions of isatins, aryl amines, dimethyl acetylenedicarboxylate and hydrazine in the presence of Zn(BDC) MOF as catalyst. The key superiority of this process is high yields, easy workup, short reaction times, and purification of the products by the nonchromatographic system. The study of the reusability of the catalyst showed that the Zn(BDC) can be readily recovered and reused six times with a slight decrease in its activity. Furthermore, the catalyst was characterized by SEM, EDX, FTIR and XRD analysis.