Voltammetric determination of zolpidem by using glassy carbon electrode modified with Ag/ZnO nanoplates

Zolpidem is an imidazopyridine derivative, non-benzodiazepine and sedative-hypnotic medicine. It is a widely prescribed medication in adults used for the short-term treatment of a sleep problem called insomnia and frequent awakenings. In this work, the zolpidem was determined using Ag/ZnO nanoplates modified glassy carbon electrode (Ag-ZnO/GCE). Electrochemical behavior of the zolpidem was investigated by differential pulse voltammetry (DPV), chronoamperometry (CHA), and cyclic voltammetry (CV) using the Ag-ZnO/GCE. The results revealed that, the current responses of the zolpidem improved significantly due to the high catalytic activity and electron transfer reaction of nanoplates. The linear range of zolpidem was found to be from 0.1 µM to 500.0 µM with the detection limit of 0.03 µM. In addition, this original sensor showed numerous benefits such as reproducibility, high stability, and rapid response (20 s).