Title of article :
PHYTOCHEMICAL AND BIOLOGICAL INVESTIGATIONS OF ERYTHRINA VARIEGATA
Author/Authors :
Rahman, Mohammed Z. The University of Asia Pacific - Department of Pharmacy, Bangladesh , Sultana, Shirin J. University of Dhaka - Faculty of Pharmacy - Department of Clinical Pharmacy and Pharmacology, Bangladesh , Faruquee, Chowdhury F. University of Dhaka - Faculty of Pharmacy, Phytochemical Research Laboratory - Department of Pharmaceutical Chemistry, Bangladesh , Ferdous, Faisol University of Dhaka - Phytochemical Research Laboratory, Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Bangladesh , Rahman, Mohammad S. University of Dhaka - Phytochemical Research Laboratory,Faculty of Pharmacy - Department of Pharmaceutical Chemistry, Bangladesh , Islam, Mohammad S. University of Dhaka - Faculty of Pharmacy - Department of Clinical Pharmacy and Pharmacology, Bangladesh , Rashid, Mohammad A. University of Dhaka - Faculty of Pharmacy, Phytochemical Research Laboratory - Department of Pharmaceutical Chemistry, Bangladesh
Abstract :
Five compounds were isolated from the n-hexane and chloroform soluble fractions of a methanol extract of the stem bark of Erythrina variegata. The structures of the isolated compounds were elucidated as alpinum isoflavone (1), epilupeol (2), 6-hydroxygenistein (3), 3â, 28- dihydroxyolean-12-ene (4) and stigmasterol (5) by extensive spectroscopic studies, including high field NMR analyses. Different partitionates of the methanol extract exhibited mild to moderate antimicrobial activity and varying degrees of cytotoxicity. Although, alpinum isoflavone (1) has previously been reported from E. variegata, this is the first report of isolation of compounds 2-4 and stigmasterol from this plant species.
Keywords :
Erythrina variegata , Fabaceae , alpinum isoflavone , 6 , hydroxygenistein , 3â , 28 , dihydroxyolean , 12 , ene , epilupeol , stigmasterol.
Journal title :
Saudi Pharmaceutical Journal(SPJ)
Journal title :
Saudi Pharmaceutical Journal(SPJ)
