Silica nanoparticles as highly efficient catalyst for the one-pot synthesis of α-aminophosphonate derivatives from primary amines, quinoline-4-carbaldehyde and phosphite under solvent-free conditions

KabachnikFields reaction between an amine, quinoline4carbaldehyde, and a phosphite in the presence of the prepared silica nanoparticles from rice hulls  (silica NP; ca. 42 nm) proceeds smoothly to afford the corresponding αaminophosphonates in high yields. The reactions were carried out in one pot and under solventfree conditions at 5080 ˚C.