Author/Authors :
Ghanem, Kadry Z National Research Center - Food Science and Nutrition Dept, Egypt , Abdel-aziz, Sahar A. National Research Center - Food Science and Nutrition Dept, Egypt , Mohamed, Magda S. National Research Center - Food Science and Nutrition Dept, Egypt , Mohammad, Mahmoud A. National Research Center - Food Science and Nutrition Dept, Egypt , Mahmoud, Mohamed H. National Research Center - Food Science and Nutrition Dept, Egypt
Abstract :
The data from the epidemiological study Indicate that increases in serum cholesterol levels are associated with increased risk of death from coronary heart disease. A number of studies in humans and animals have shown that rice bran oil (RBG) is as effective as other vegetable oils in lowering plasma cholesterol levels. The present study was undertaken to compare the effects of two concentrations (6%) and (3%) of Egyptian-RBO on hypercholesterolemia and calcium content of tibia in rats. Ffeur groups of six rats were used, the first group was fed on basal diet (control), while the second group was fed on basal diet plus 1% cholesterol. The groups 3 and 4 were fed on basal diet +1 % cholesterol + RBO (3 and 6 % respectively). Non significant differences were noticed in the mean value of body weight, organ weight and relative organ weights (organ wt/body wt) between different experimental groups. The results obtained showed no signifiqint change in transaminase (AST ALT) activities between different treated groups. No significant effect was observed in plasma urea and creatinine or hemoglobin in different treated groups compared to control group. Significant decrease in malodialdehyde (MDA) value was observed in group 4 (6 %, rice bran oil) compared to control. Total cholesterol and low density lipoprotein cholesterol showed significant increase in hypercholesterolemic group (52 % and 169 %) compared to control. Supplementation of rice bran oil in groups 4 decreased its level compared to cholesterol group 2. The data obtained revealed that triacylglycerol was significantly decreased due to supplementation with rice bran oil of groups 3 (by 17.26 %) and 4 (by 16.07%) compared to hypercholesterolemia in rats of group 2.The results showed that the rats fed on the rice oil (6%) diet had significantly higher bone calcium (by 17.48 % of control) of right tibia, tibial Phosphorus, magnesium and zinc in all treated groups were not significantly changed compared to control. Conclusion: Rice bran oil seems to be a very promising phytochemical alternative to classic lipid-lowering agents and increasing tibial calcium.
