The Effect of Combined Exercise Course and Aloe-Vera Supplementation on Renal Function and Lipid Profile in Type 2 Diabetes Mellitus Patients: A Randomized Clinical Trial

Objective: Renal failure is a complication of diabetes. It can be the risk factor of cardiovascular disease. This study aimed to evaluate the effect of exercise course and Aloe-Vera supplementation on renal function and lipid profile in type 2 diabetes mellitus (T2DM) patients. Materials and Methods: This is a clinical trial double blind with pre-test and post hoc test analyses with a control group. The studied population included a group of T2DM diagnosed patients among whom 24 men (40-60years) were selected voluntarily and purposefully and were classified into three groups by balanced block randomization method, exercise(E), exercise + supplement (E+S), and control (C), (n=8/group). Combined exercise was planned in two 12-minute repetitive sets with 70% 1RM. Then the participants ran for two 10- minute sets with 70-75% maximum heart rate intensity on treadmill. E+S participants consumed 500 mg/day Aloe Vera for 6 weeks. Obtained data by SPSS-19 software were analyzed using co-variance analysis method with Bonferroni post hoc test (Pvalue 0/05). Results: Results showed that E and E+S significantly improved GFR (P-value=0.011) and E with or without Aloe-Vera consumption decreased creatinine levels (P- value=0.042) and increased HDL levels (P- value˂0.001). The results demonstrated that LDL and TG levels showed no significant difference in reaction to the combined exercise and supplementation. Conclusion: Combined exercise along with Aloe-Vera supplementation has had significant effect on improving renal factors and lipid profile of T2DM diagnosed patients.