Author/Authors :
Zieleskiewicz, Laurent Department of Anesthesiology and Intensive Care - North Hospital - APHM - Aix Marseille Univ - INSERM - INRA - Marseille , Claret, Pierre-Géraud Faculty of Medicine - Montpellier-Nimes University,EA 2992 - Nîmes University Hospital and PhyMedExp - INSERM U1046 - CNRS UMR9214 - Montpellier University - Montpellier, France , Muller, Laurent Faculty of Medicine - Montpellier-Nimes University,EA 2992 - Nîmes University Hospital and PhyMedExp - INSERM U1046 - CNRS UMR9214 - Montpellier University - Montpellier, France , Coussaye, Jean Emmanuel de La Faculty of Medicine - Montpellier-Nimes University,EA 2992 - Nîmes University Hospital and PhyMedExp - INSERM U1046 - CNRS UMR9214 - Montpellier University - Montpellier, France , Lefrant, Jean Yves Faculty of Medicine - Montpellier-Nimes University,EA 2992 - Nîmes University Hospital and PhyMedExp - INSERM U1046 - CNRS UMR9214 - Montpellier University - Montpellier, France , Schuster, Iris Department of Sports Medicine and Cardiology (CEMAPS 30) - Nîmes University Hospital and PhyMedExp - INSERM U1046 - CNRS UMR9214 - Montpellier University - Montpellier, France , Roger, Claire Faculty of Medicine - Montpellier-Nimes University,EA 2992 - Nîmes University Hospital and PhyMedExp - INSERM U1046 - CNRS UMR9214 - Montpellier University - Montpellier, France , Bobbia, Xavier Faculty of Medicine - Montpellier-Nimes University,EA 2992 - Nîmes University Hospital and PhyMedExp - INSERM U1046 - CNRS UMR9214 - Montpellier University - Montpellier, France
Abstract :
Global longitudinal strain (GLS) appears sensitive and reproducible to identify left ventricular systolic dysfunction. The main objective was to analyze the GLS changes in an anesthetized-piglet model of controlled hemorrhagic shock (HS). The secondary objective was to evaluate if GLS changes was different depending on the expansion fluid treatment with or without norepinephrine.METHODS: Eighteen anesthetized and ventilated piglets were bled until the mean arterial pressure reached 40 mmHg. Controlled hemorrhage was maintained for 30 min before randomizing the piglets to three resuscitation groups: control group, LR group (resuscitated with lactated ringer), and NA group (resuscitated with lactated ringer and norepinephrine).RESULTS: There was no difference in the baseline hemodynamic, biological, and ultrasound data among the three groups. During the hemorrhagic phase, the GLS increased significantly from 25 mL/kg of depletion. During the resuscitation phase, the GLS decreased significantly from 20 mL/kg of fluid administration. There was no difference in GLS variation among the groups during the hemorrhagic, maintenance, and resuscitation phases.CONCLUSION: In our HS model, GLS increased with hemorrhage and decreased during resuscitation, showing its preload dependence.
