Author/Authors :
Jadali, Z tehran university of medical sciences tums - School of Public Health - Dept of Immunology, تهران, ايران , Eslami, MB tehran university of medical sciences tums - School of Public Health - Dept of Immunology, تهران, ايران , Sanati, MH National Research Center for Genetic Engineering and Biotechnology, ايران , Mansouri, P Imam Khomeini General Hospital - Dept of Dermatology, ايران , Mahmoudi, M tehran university of medical sciences tums - School of Public Health - Dept of Biostatics and Epidemiology, تهران, ايران , Maghsoudi, N malekeashtar university of technology - Biotechnology Group, تهران, ايران , Esfahanian, F Imam Khomeini General Hospital - Dept of Endocrinology, ايران
Abstract :
Vitiligo is a common skin disorder, characterized by depigmented patches due to selective destruction of melanocytes. The etiology of this disease is unknown. A number of hypotheses including viral theory have been proposed to explain the etiology. To determine the prevalence of antibody to hepatitis C virus infection in vitiligo patients, the present study was performed. Third generation ELISA test was used for detection of antibodies to HCV in human sera. All normal controls were anti-HCV negative whereas only one patient was positive for anti-HCV and there was no significant difference in the prevalence of anti-HCV between patients and controls. These results indicate that hepatitis C virus has not a direct causal role in the pathogenesis of vitiligo, however, this does not rul out a hit and run virus induced disease.
Keywords :
Hepatitis C virus , Vitiligo , ELISA , Iran
