Title of article :
Effect of Vitamins A, E, C and Omega-3 Fatty Acids on Lipid Peroxidation in Streptozotocin Induced Diabetic Rats.
Author/Authors :
Fakher, SH. tehran university of medical sciences tums - School of Public Health and Institute of Public Health Research - Dept of Nutrition and Biochemistry, تهران, ايران , Djalali, M. tehran university of medical sciences tums - School of Public Health and Institute of Public Health Research - Dept of Nutrition and Biochemistry, تهران, ايران , Tabei, SMB. shiraz university of medical sciences - Faculty of Medicine - Dept of Biochemistry, شيراز, ايران , Zeraati, H. tehran university of medical sciences tums - School of Public Health and Institute of Public Health Research - Dept of Epidemiology and Biostatistics, تهران, ايران , Javadi, E. tehran university of medical sciences tums - Research Center of Endocrinology, تهران, ايران , Sadeghi, MR. Avicenna Research Institute - Reproductive Biotechnology Research Center, تهران, ايران , Mostafavi, E. tehran university of medical sciences tums - Faculty of Medicine - Dept of Pathology, تهران, ايران , Fatehi, F. tehran university of medical sciences tums - School of Public Health and Institute of Public Health Research - Dept of Nutrition and Biochemistry, تهران, ايران
Abstract :
Background: To assess the effect of supplementation with vitamins A, E and C and (omega)-3 fatty acids on lipid peroxidation in streptozotocin (STZ) induced diabetic rats. Methods: Sixty four male wistar rats weighting 250g were divided into four groups as normal control, diabetic control, diabetic with vitamin A, E as well as C supplementation and diabetic with (omega)-3 fatty acids supplementation. After four weeks of treatment the rats were anesthetized and malondialdehyde (MDA) levels were investigated in blood samples, liver and heart homogenate.Results: In diabetic rats MDA level in plasma, liver and heart was significantly more elevated than normal control rats (P 0.05). Vitamin A, E and C supplementation caused significant decrease in plasma, liver and heart MDA (P 0.05). A significant decrease in heart MDA (P 0.05) was observed in diabetic rats with (omega)-3 fatty acids supplementation. Conclusion: Supplementation of vitamin A, E and C and (omega)-3 fatty acids was found to decrease lipid peroxidation to some extent in diabetic rats and they can be valuable candidates in the treatment of the complications of diabetes .
Keywords :
Vitamin C , Vitamin E , Vitamin A , Omega3 fatty acid , Malondialdehyde.
