Author/Authors :
Jadali, Z. tehran university of medical sciences tums - School of Public Health - Dept of Immunology, تهران, ايران , Izad, M. tehran university of medical sciences tums - School of Medicine - Dept of Immunology, تهران, ايران , Eslami, MB. tehran university of medical sciences tums - School of Public Health - Dept of Immunology, تهران, ايران , Mansouri, P. tehran university of medical sciences tums - Imam Khomeini Hospital - Dept of Dermatology, تهران, ايران , Safari, R. tehran university of medical sciences tums - Imam Khomeini Hospital - Dept of Endocrinology, تهران, ايران , Bayatian, P. tehran university of medical sciences tums - School of Public Health - Dept of Immunology, تهران, ايران , Mirshafiey, A. tehran university of medical sciences tums - School of Public Health - Dept of Immunology, تهران, ايران , Salehi Nodeh, AR. tehran university of medical sciences tums - School of Public Health - Dept of Immunology, تهران, ايران
Abstract :
Background: The aim of this study was to determine the Th1 and Th2 serum cytokines, in patients with psoriasis and to compare their cytokine levels with those of nonnal control subjects. Methods: Serum levels of Interferon-gamma (IFN-(gamma)), Interleukin-2 (IL-2) , Interleukin-4 (IL-4), and Interieukin-10 (IL-10) were measured by enzyme linked immunosorbent assay in 40 patients with psoriasis and in 40 normal controls. Results: Compared with control subjects, patients with psoriasis had elevated levels of IFN-(gamma) and IL-2 (P 0.001). In addition a positive correlation was found between the levels of IFN-(gamma), IL-2 and disease severity. Conclusion: Th 1 secreting inflammatory cytokines may contribute to the pathogenesis of psoriasis.
