Author/Authors :
Talebi, M university of tehran - School of Public Health, Medical Sciences - Dept of Pathobiology, تهران, ايران , Eshraghi, SS university of tehran - School of Public Health, Medical Sciences - Dept of Pathobiology, تهران, ايران , Pourshafie, MR Pasteur Iinstitute of Iran - Dept of Microbiology, تهران, ايران , Pourmand, MR university of tehran - School of Public Health, Medical Sciences - Dept of Pathobiology, تهران, ايران , Eshraghian, MR university of tehran - School of Public Health, Medical Sciences - Dept of Biostatistics, تهران, ايران
Abstract :
Background: To determine the species distribution, updated drug susceptibility patterns and genes conferring resistance in clinical vancomycin resistant enterococcal (VRE) isolates. Methods: Clinical enterococcal isolates collected during 7 months, from September 2005 to April 2006 from hospitalized patients and outpatients were studied. Twenty five VRE were isolated from 450 enterococci samples (5.6%). VRE isolates were subjected to antibiotic susceptibility tests. Genotype of these isolates was determined by PCR. Results: All of the isolates were E. faecium and carried the vanA gene. Antibiotic susceptibility tests showed that the isolates were resistant to ampicillin 25(100%), ciprofloxacin 25(100%), gentamicin 24(96%), erythromycin 25(100%), tetracy-clin 10(40%o) and chloramphenicol 2(8%). Conclusion: VRE strains were resistant to three antibiotics and were susceptible to new antibiotics linezolid and dalfopris-tin-quinupristin. Switching to treatment with these antibiotics would relieve the problem for a short time.
