Author/Authors :
Sovri ، Nafiseh Gastroenterology and Hepatology Research Center - Kerman University of Medical Sciences , Saberi ، Arezoo Physiology Research Center, Institute of Neuropharmacology - Kerman University of Medical Sciences , Saeidpour ، Ali Gastroenterology and Hepatology Research Center - Kerman University of Medical Sciences , Ahmadi ، Bijan Gastroenterology and Hepatology Research Center - Kerman University of Medical Sciences , Khalesi ، Ali Akbar Gastroenterology and Hepatology Research Center - Kerman University of Medical Sciences , Maleki ، Elham Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences - Kerman University of Medical Sciences , Salarkia ، Ehsan Leishmaniasis Research Center - Kerman University of Medical Sciences , Divsalar ، Kouros Neuroscience Research Center, Institute of Neuropharmacology and Cardiovascular Research Center, Institute of Basic and Clinical - Kerman University of Medical Sciences
Abstract :
Background: Methamphetamine (METH) is a widely addictive and abused psychostimulant drug that affects organs of body. In this study, the effects of METH administration for 7, 14, and 28 days on the histological and functional changes of the liver and pancreas of adult male rats were investigated. Methods: In this experimental study, 58 adult male Wistar rats were randomly divided into seven groups including control (received no treatment), vehicle (received saline for 7, 14, and 28 days), and METH (received METH with a dose of 5 ml/kg, IP for 7, 14 or 28 days). Sampling from the liver and pancreas tissues was done after the abovementioned times for each group, then, tissue samples were stained by H E technique and evaluated for structural changes, as well as the evaluation of biochemical factors including SGPT, SGOT, and amylase enzymes. Data were analyzed by oneway ANOVA, using SPSS software version 20. Statistical significant level was considered at Results: In this study, METH caused a significant structural change in the liver and pancreas in the METHtreated groups compared with the control group. Functional changes depended on the length of treatment, with the 7day treatment group having less damage than the 14 and 28day periods. Conclusion: According to the results of the present study, methamphetamine administration for 7, 14, and 28 days had adverse effects on the rats liver and pancreas structure and their enzymes (SGPT, SGOT, and amylase). Therefore, underlying mechanism need further investigation.
Keywords :
Methamphetamine , Histological Index , Liver , Pancreas
