Title of article :
Syntheses of Substituted 1,3,4-Oxadiazole, 1,3,4-Thiadiazole and 1,2,4-Triazole Derivatives as Potential Antimicrobial Agents.
Author/Authors :
Vosooghi, M. tehran university of medical sciences tums - Faculty of Pharmacy and Pharmaceutical Sciences Research Center - Department of Medicinal Chemistry, تهران, ايران , Akbarzadeh, T. tehran university of medical sciences tums - Faculty of Pharmacy and Pharmaceutical Sciences Research Center - Department of Medicinal Chemistry, تهران, ايران , Fallah, A. tehran university of medical sciences tums - Faculty of Pharmacy and Pharmaceutical Sciences Research Center - Department of Medicinal Chemistry, تهران, ايران , Fazeli, M. R. tehran university of medical sciences tums - Faculty of Pharmacy and Pharmaceutical Sciences Research Center - Departments of Pharmaceutical Biotechnology, تهران, ايران , Jamalifar, H. tehran university of medical sciences tums - Faculty of Pharmacy and Pharmaceutical Sciences Research Center - Departments of Pharmaceutical Biotechnology, تهران, ايران , Shafiee, A. tehran university of medical sciences tums - Faculty of Pharmacy and Pharmaceutical Sciences Research Center - Department of Medicinal Chemistry, تهران, ايران
Abstract :
A series of 2-(4-nitro-1-imidazolylmethyl)-1,3,4-oxadiazole, 1,3,4-triazole and 3-(4-nitro-1-imidazolylmethyl)-1,2,4-triazole derivatives were synthesized and tested for their antimicrobial activity. Some of the tested compounds were active against Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Clostridium difficile, Aspergillus niger and Cryptococcus neoformans.
Keywords :
Antimicrobial agents , 1,3,4 , Oxadiazoles , 1,3,4 , Thiadiazoles , 1,2,4 , Triazoles.
Journal title :
Journal of Sciences Islamic Republic of Iran
Journal title :
Journal of Sciences Islamic Republic of Iran
