Title of article
Molecular modeling of 8-methoxy quinolone analogues by using quantitative structure activity relationship
Author/Authors
Srivastava, A. K. University of Allahabad - Department of Chemistry, QSAR Research Laboratory, India , Pathak, Vinay Kumar University of Allahabad - Department of Chemistry, QSAR Research Laboratory, India , Srivastava, Akanchha University of Allahabad - Department of Chemistry, QSAR Research Laboratory, India , Pandey, Avni University of Allahabad - Department of Chemistry, QSAR Research Laboratory, India
From page
217
To page
222
Abstract
Quantitative structure activity relationship (QSAR) studies on a series of 8-methoxy quinolone are found to correlate well with steric parameters and electronic parameter. The results are critically discussed on the basis of regression data, Pogliani factor Q and cross validation technique. The results are found to be useful in discussing the mechanism of drug – receptor interaction. Steric parameter ‘Mr’ and electronic parameter ‘Pz’ gives the best model.
Keywords
QSAR , Steric parameters , Electronic parameter , Cytotoxicity
Journal title
Journal of Saudi Chemical Society
Journal title
Journal of Saudi Chemical Society
Record number
2580272
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