Author/Authors :
Srivastava, A. K. University of Allahabad - Department of Chemistry, QSAR Research Laboratory, India , Pathak, Vinay Kumar University of Allahabad - Department of Chemistry, QSAR Research Laboratory, India , Srivastava, Akanchha University of Allahabad - Department of Chemistry, QSAR Research Laboratory, India , Pandey, Avni University of Allahabad - Department of Chemistry, QSAR Research Laboratory, India
Abstract :
Quantitative structure activity relationship (QSAR) studies on a series of 8-methoxy quinolone are found to correlate well with steric parameters and electronic parameter. The results are critically discussed on the basis of regression data, Pogliani factor Q and cross validation technique. The results are found to be useful in discussing the mechanism of drug – receptor interaction. Steric parameter ‘Mr’ and electronic parameter ‘Pz’ gives the best model.
Keywords :
QSAR , Steric parameters , Electronic parameter , Cytotoxicity
