Title of article :
A convenient, rapid microwave assisted synthesis of some novel 3-[(4-chloro-3-methylphenoxy)methyl]-6-aryl- 5,6-dihydro-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles using acidic alumina
Author/Authors :
Raval, Jignesh P. Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences - Department of Pharmaceutical Chemistry, India , Patel, Hemul V. Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences - Department of Pharmaceutical Chemistry, India , Patel, Pradip S. Ashok and Rita Patel Institute of Integrated Study and Research in Biotechnology and Allied Sciences - Department of Pharmaceutical Chemistry, India , Desai, Kishor R. Veer Narmad South Gujarat University - Department of Chemistry, India
Abstract :
A facile synthesis of 3-[(4-chloro-3-methylphenoxy)methyl]-6-aryl-5,6-dihydro-[1,2,4]- triazolo[3,4-b][1,3,4]thiadiazoles 3a–n has been achieved by microwave promoted condensation of 3-mercapto-4-amino-5-[(4-chloro-3-methylphenoxy)methyl]-4H-1,2,4-triazole 1 with various aromatic aldehydes 2a–n in presence of catalytic amount of p-TsOH (para-toluenesulphonic acid). The structures of 3a–n are supported by IR and 1H and 13C NMR spectral data.
Keywords :
Microwave , Triazolo[3,4 , b][1,3,4]thiadi azole , Acidic alumina
Journal title :
Journal of Saudi Chemical Society
Journal title :
Journal of Saudi Chemical Society
