Title of article
QSAR based modeling of hepatitis C virus NS5B inhibitors
Author/Authors
Srivastava, A. K. University of Allahabad - Department of Chemistry, QSAR Research Laboratory, India , Pandey, Avni University of Allahabad - Department of Chemistry, QSAR Research Laboratory, India , Srivastava, Akanchha University of Allahabad - Department of Chemistry, QSAR Research Laboratory, India , Shukla, Neerja University of Allahabad - Department of Chemistry, QSAR Research Laboratory, India
From page
25
To page
28
Abstract
QSAR analysis on a series of 13 derivatives of 5-hydroxy-3-(2H)-pyridazinone as hepatitis C virus NS5B polymerase inhibitors was performed. The inhibitory activities of these compounds were found to increase with density (D), index of refractivity (Ior), surface tension (St), electronegativity (Xeq) and decrease with the balaben centric index (Bac), balaben distance connectivity index (J) and zero order connectivity (X^0) along with the indicator parameter. Excellent results were obtained from regression upon introduction of the indicator parameter. The results are critically discussed on the basis of regression data and cross validation technique.
Keywords
QSAR , Physicochemical properties , Regression analysis , HCV NS5B polymerase inhibitors
Journal title
Journal of Saudi Chemical Society
Journal title
Journal of Saudi Chemical Society
Record number
2580313
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