Author/Authors :
Goverdhan, Gilla Dr. Reddy’s Laboratories Ltd, India , Reddy, Anumula Raghupathi Dr. Reddy’s Laboratories Ltd, India , Himabindu, Vurimidi Jawaharlal Nehru Technological University - Institute of Science and Technology, Center for Environmental Science, India , Reddy, Ghanta Mahesh Macleods Pharmaceuticals Limited, India
Abstract :
Zafirlukast is an oral leukotriene receptor antagonist (LTRA) for the treatment of pulmonary disorders such as asthma. During the process development of zafirlukast, eight process related impurities were observed at a level of 0.1–0.15 area percent. Synthesis and characterization of these impurities and investigation of the root cause of their formation is described.
Keywords :
Zafirlukast , Asthma drug , Process impurities , Leukotriene
