Effect of D-penicillamine in prevention of post operative pelvic adhesion formation in rat

Adhesion formation after pelvic surgery is still a major cause of several morbidities such as infertility, pain, bowel obstruction and subsequent intra-operative complications. Our aim was to investigate the effects of d-penicillamine in preventing adhesion formation in rat uterine horn. METHODS: This experimental trial was conducted on 30 rats. The rats were randomly assigned to two groups of 15. Measurable serosal injury was created using a standard technique. The rats in one of the two groups were given 17 mg/kg of d-penicillamine. All of the animals were operated on 4 weeks after surgery and adhesions were assessed and scored by an examiner who was blind to the test. RESULTS: Frequency of severe adhesions in control and case groups were 76 and zero percent, respectively. Total scores of adhesions were found to be significantly reduced in the d-penicillamine treatment group when compared with control group (P = 0). CONCLUSION: This study showed that penicillamine can decrease the chance of post-operative intra-peritoneal adhesion formation.