Author/Authors :
Niazi ، Feizollah Department of Plastic and Reconstructive Surgery - School of Medicine, Modarres Hospital - Shahid Beheshti University of Medical Sciences , Hedayatyanfard ، Keshvad Department of Physiology-Pharmacology-Medical Physics - Cardiovascular Research Center, School of Medicine - Alborz University of Medical Sciences , Soroush ، Mohammad Department of Plastic and Reconstructive Surgery - School of Medicine, Modarres Hospital - Shahid Beheshti University of Medical Sciences , Habibi ، Behnam Department of Pharmacology - School of Medicine - Shahid Beheshti University of Medical Sciences , Haddadi ، Nazgol-Sadat Department of Dermatology - School of Medicine - University of Massachusetts , Rostami ، Khalil Department of Plastic and Reconstructive Surgery - School of Medicine, Modarres Hospital - Shahid Beheshti University of Medical Sciences , Rajabi ، Sadegh Traditional Medicine and Materia Medica Research Center (TMRC) - Shahid Beheshti University of Medical Sciences , Khalili ، Azadeh Department of Physiology-Pharmacology-Medical Physics - School of Medicine - Alborz University of Medical Sciences , Niazi ، Sana Department of Plastic and Reconstructive Surgery - School of Medicine, Modarres Hospital - Shahid Beheshti University of Medical Sciences
Abstract :
Background: Keloid and hypertrophic scars (HTS) caused by an imbalance between the production and destruction of collagen during wound healing with an unknown underlying pathophysiological mechanism. This study was designed to evaluate the histamine level in the Keloid and HTS and comparison of results with normal skin. Materials and Methods: This pilot study included 36 participants, aged from 18 to 70 years with keloid (n=11), HTS (n=13) and normal (n=12) skin. The level of histamine in the skin samples was measured using enzyme-linked immunosorbent assay (ELISA). Results: Histamine level in keloid samples was significantly higher than in the normal (p=0.0012) or HTS (p=0.0028) groups. However, there was no significant difference between the normal and HTS samples (p=0.92). Conclusion: The increased histamine level in the keloid tissue may contribute to its pathogenesis and the application of anti-histamines could be of benefit for the prevention and treatment of keloids.
Keywords :
Histamine , Hypertrophic scar, Keloid, ELISA, Antihistamine
