Title of article :
A new phenylpropanoid glucoside from Psorospermum tenuifolium Kotschy (Hypericaceae)
Author/Authors :
Happi ، GERVAIS MOUTHÉ Department of Chemistry - Higher Teacher Training College - University of Bamenda , MBOBDA ، ALEXIS SYLVAIN W. Department of Chemistry - Higher Teacher Training College - University of Yaounde I , Frese ، Marcel Faculty of Chemistry - Bielefeld University , Kouam ، SIMEON FOGUE Department of Chemistry - Higher Teacher Training College - University of Yaounde I , Tchouankeu ، JEAN CLAUDE Department of Organic Chemistry - Faculty of Sciences - University of Yaounde I , LENTA ، BRUNO NDJAKOU Department of Chemistry - Higher Teacher Training College - University of Yaounde I , Sewald ، Norbert Faculty of Chemistry - Bielefeld University
Abstract :
A new phenylpropanoid glycoside, namely psorospermoside (1) was obtained from the Psorospermum tenuifolium bark extract together with eleven known compounds. Their structures were elucidated using spectroscopic and spectrometric methods including 1D, 2D-NMR and ESI-MS, as well as by comparison of their data with those reported in the literature. All the isolated compounds were assessed for their cytotoxicity effect on the human cervix carcinoma cell line KB3-1. Emodin (2) and its congener 2-geranylemodin (3) displayed significant cytotoxicity with IC50 values of 11.4 μM and 19 μM, respectively. Furthermore, the chemophenetic significance of the isolated compounds was also discussed.
Keywords :
Psorospermum tenuifolium , Phenylpropanoid glucoside , Psorospermoside , Emodin , 2 , Geranylemodin , Cytotoxicity
Journal title :
Trends In Phytochemical Research
Journal title :
Trends In Phytochemical Research
