Title of article :
Evaluation of In Vitro Antioxidant Activity of 5H-dibenz[b,f]azepine and Its Analogues
Author/Authors :
Honnaiah, Vijay Kumar University of Mysore - Department of Studies in Chemistry, India , Ambati, Ranga Rao Acharya Nagaijuna University - V R S Y R N College - Department of Oils and Fats, India , Sadineni, Varakumar Sri Venkateswara University - Department of Biochemistry, India , Naik, Nagaraja University of Mysore - Department of Studies in Chemistry, India
Abstract :
Synthesis of 5H-dibenz[b,f]azepine and its derivatives bearing different functional groups was performed. The compounds thus synthesised were evaluated for their antioxidant activities by following two well established assays: inhibitory activity on human low density lipoprotein (LDL) oxidation and lipid peroxidation activity in an egg liposome model system. Among the compounds, (a) and (d) significantly inhibited human LDL oxidation and liposome peroxidation, whereas compounds (b), (c), (e) and (f) showed less activity. Butylated hydroxy anisole (BHA) and ascorbic acid (AA) were used as reference antioxidant compounds. Comparative studies with the synthesised compounds were also performed.
Keywords :
5H , dibenz[b , f]azepine , LDL oxidation , lipid peroxidation , antioxidant activity
Journal title :
Journal of Physical Science
Journal title :
Journal of Physical Science
