Author/Authors :
Khoshnegah, J. ferdowsi university of mashhad - Faculty of Veterinary Medicine - Department of Clinical Sciences, مشهد, ايران , Jamshidi, Sh. university of tehran - Faculty of Veterinary Medicine - Department of Clinical Sciences, تهران, ايران , Shojaee Tabrizi, A. university of tehran - Faculty of Veterinary Medicine - Department of Clinical Sciences, تهران, ايران , Mohajerani, N. Pasteur Iinstitute of Iran - Biotechnology Research Center, تهران, ايران , Zahraei Salehi, T. university of tehran - Faculty of Veterinary Medicine - Department ofMicrobiology, تهران, ايران
Abstract :
To improve our understanding of Helicobacter infection in cats and to determine whether they arereservoirs for H. pylori and sources of zoonotic transmission to humans, we selected cats as an experimentalanimal model for gastric colonization by H. pylori. Sixteen stray cats underwent Helicobacter eradicationtreatment followed by three consecutive oral inoculations of a cocktail of human H. pylori isolates. Four outof sixteen inoculated cats became colonized by H. pylori as confirmed by genus- and species-specific PCR.In conclusion, human H. pylori isolates are able to colonize the stomach of cats. It seems that the stray catcan be used as an experimental model in the future investigations of H. pylori-induced pathogenesis as wellas evaluation of anti-H. pylori prevention and treatment regimens. Further experimental studies using moreanimals are needed to identify the usefulness of the cat as an experimental model.
Keywords :
H. pylori , Colonization , PCR , Cat
