The Healing Potential of Oleaster Leave Water Soluble Extracton Experimental Skin Wounds in the Rat

To evaluate the healing potential of oleaster leave water soluble extract on skin wounds.Design- Experimental study.Animals- 30 male Spragne-Dawly rats, randomly assigned in two equal groups.Procedures- Under general anesthesia, and following surgical preparation, two uniform skin defectswere made by 7mm skin punch. The water soluble extract was then applied on half of the wounds for7 days. The animals were sacrificed on day 8 and histopathologica and biomechanical samples weretaken. Wound planimetry was also performed.Results- All the evaluated parameters in histopathological and biomechanical studies weresignificantly superior in treatment group in comparison with the control one. The surface area of thetreatment wounds were also significantly less than the control wounds.Conclusion and Clinical Relevance- This study showed that oleaster leave extract has a pro-healingeffect on the experimental skin wounds and it can be considered as an available herbal preparationwith reasonable cost.