Caudal Extradural Analgesia with Lidocaine, Xylazine, and a Combination of Lidocaine and Xylazine in the Iranian River Buffalo (Bubalus bubalis)

To compare the time of onset, duration of action and the extent of analgesiaproduced by a lidocaine/xylazine combination with that produced by lidocaine and xylazinealone after injection into the caudal extradural space of the Iranian river buffalo.Design- Observer-blind prospective descriptive trial, Latin square design.Animals- Eleven adult (aged over 2 years) female non-gravid healthy Iranian riverbuffaloes (Bubalus bubalis), weighing from 450 to 650 kg.Procedure- Caudal extradural analgesia was achieved in buffaloes on 3 occasions at 14-dayintervals by injection of 2% lidocaine (L; 0.22 mg kg-1), 2% xylazine (X; 0.05 mg kg-1), anda combination of 2% lidocaine(0.22 mg kg-1) / 2% xylazine (LX; 0.05 mg kg-1) in a Latinsquare design. Analgesia was determined by the lack of response to pin-prick andhaemostat pressure in the skin of the caudal areas.Results- Onset of analgesia for X was significantly longer (5.5 ± 0.7 minutes) than that forL or LX. Duration of analgesia was significantly longer for LX (172.3 ± 17.7 minutes) thanfor either drug used alone (lidocaine, 79.5 ± 5.7 minutes; xylazine, 136.4±11.4 minutes). InX and LX groups, the level of analgesia ascended to thoracic segments; however, inlidocaine-treated buffaloes thighs, flank, and udders remained sensitive. In all buffaloes,xylazine, administered either alone or with lidocaine, induced mild to moderate ataxia.Conclusions – The LX combination provided a more rapid onset, a longer duration ofanalgesia, and a more cranial spread of analgesic effect compared with either drug alone.Clinical relevance: The LX combination may offer a fast and long lastinganesthesia/analgesia to perform obstetrical and surgical procedures without the need for reinjection.