Synthesis of Polyfunctional Dendrimeric Type Copolymer as the Hydrogels and Investigation of their Thermoreversible Behaviours.

The syntheses of a novel telechelic polymer and a polyfunctional dendrimeric copolymer were achieved. For the synthesis of telechelic polymer, first a diacid of poly(ethylene glycol) was chlorinated using thionyl chloride. Then 5-aminosalicylic acid (5-ASA) was reacted with diacyl halide poly(ethylene glycol). The resulting polymer containing drug molecule (5-ASA) (1) reacted with dicyclohexyl carbodiimide (DCC) in dichloromethane and a polyfunctional copolymer (2) was obtained. The GPC measurements confirmed the formation of a pentamer containing telechelic blocks type compound. The thermoreversible behaviours of the prepared hydrogels of both telechelic polymer and the polyfunctional dendrimeric copolymer have been investigated. The thermoreversible behaviour of telechelic polymer 1 in water was almost in contrast to the thermoreversible behaviour of compound 2. The structure definition and analysis of the synthesized new compounds was carried out using NMR, FTIR, UV-Vis spectrometry, optical microscopy and viscosimetry methods.