Title of article
Synthesis and Characterization of Poly(8- Hydroxyquinoline-/(pi)-styrene sulphonate) and Study of its Controlled Release Behaviour.
Author/Authors
Khazaei, Ardeshir bu ali sina university of hamadan - Department of Chemistry - Faculty of Science, همدان, ايران , Soudbar, Davood Arak Petrochemical Company. - Center of Research and Development, Iran. , Sadri, Minoo malekeashtar university of technology - Education and Research Center of Science and Biotechnology, تهران, ايران , Seyed Mohaghegh, Seyed Mohammad Iran Polymer and Petrochemical Institute - Department of Polymer Science, تهران, ايران
From page
309
To page
317
Abstract
new controlled release compound was prepared by the reaction of p-styrene sulphonyl chloride and 8-hydroxyquinoline in the presence of triethylamine as catalyst. The obtained monomer with bioactive agent moiety was polymerized with benzoyl peroxide as initiator at reflux condition under nitrogen atmosphere. The resulting monomer and polymer were identified by spectroscopic methods (FTIR, 1H NMR). Also molecular weight of the polymer was determined by gel permeation chro-matography (GPC) and Td was identified by differential scanning calorimetry (DSC), for reason of the existence of aromatics and sulphonate groups in the polymer thermal resistance is high and before temperature reaches its melting point, the degradation of polymer occurs. The release characteristics of the polymer were studied in neutral, alkaline, and acidic media. The hydrolysis data showed that release rates are strongly dependent on the pH of the medium, and the temperature.
Keywords
controlled release , synthesis , poly(8 , hydroxyquinoline , p , styrene sulphonate) , gel permeation chromatography.
Journal title
Iranian Polymer Journal
Journal title
Iranian Polymer Journal
Record number
2583240
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