Author/Authors :
said, a. national research centre - department of pharmacognosy, Giza, Egypt , omer, e.a. national research centre - medicinal and aromatic plants research department, Giza, Egypt , el gendy, m. a. m. university of alberta - faculty of medicine and denistry - department of oncology, Edmonton, Canada , el gendy, m. a. m. national research centre - department of pharmacognosy, Giza, Egypt , fawzy, g. national research centre - department of pharmacognosy, Giza, Egypt , abd el-kader, a. e. national research centre - department of chemical engineering, pilot laboratory, Giza, Egypt , fouad, r. national research centre - medicinal and aromatic plants research department, Giza, Egypt
Abstract :
The volatile constituents which obtained from fresh fruits of Pleiogynium timorense(Dc.) Leenh (Anacardiaceae) by hydro-distillation method were investigated by Gas chromatography and gas chromatography–mass spectrometry. Twenty seven compounds were identified representing 98.6% of the total oils. D-Limonene was the major oil constituent (64.51 %), followed by γ-Terpinene (5.60%), while, α-Copaene and trans- Caryophyllene showed the same percentage (4.74 %). In addition, phytochemical screening, proximate analysis, total phenolic and total flavonoid contents of the fruits were determined. Furthermore, the volatile constituents showed a cytotoxic effect against breast adenocarcinoma MCF7 and laryngeal carcinoma HEp2 human tumor cell lines and a moderate cytotoxic effect on human hepatoma HepG2 cells.
Keywords :
Pleiogynium timorense , D , Limonene , Cytotoxic , Gambozia , volatile constituents , Anacardiaceae
