Multicomponent reactions (MCRs) of acetylenic compounds with isocyanides or triphenylphosphine–A Mini review

Acetylenic esters such as dimethylacetylenedicarboxylat (DMAD), diethyl acetylenedicarboxylat (DEAD) and alkyl propiolates are esters in which the ester groups are conjugated with a C-C triple bond. As such, these molecules are highly electrophilic, and widely employed as a dienophile in cycloaddition reactions. They have been used in muliticomponent reactions in the presence of nucleophilic compounds such as Isocyanides, Isoquinoline, Quinoline, Triphenylphosphine, trialkyl (aryl) phosphites and NH-acidic or OH-acidic compounds. This review mainly focuses on the research work reported in the scientific literature on the reaction this compounds with Isocyanides and Triphenylphosphine.