Cytotoxicity test on Artemia Salina, antibacterial and antifungal activities of Cystoseira Stricta extracts from the coast of Mostaganem, western Algeria

Cystoseira stricta sp, with its abundance and its dimensions, is undoubtedly the most important brown seaweed of the Mediterranean Sea.!Within the objective to promote this alga by researching natural products for possible pharmaceutical use, four organic extracts of Cystoseira stricta sp, harvested from the Mostaganem coast, west of Algeria, were evaluated for their cytotoxicity on Artemia salina and their antibacterial activities against three gram-positive bacteria (Bacillus cereus ATCC 1087, Bacillus subtilis ATCC 66336 and Staphylococcus aureus ATCC 33862) and two other gram-negative (Pseudomonas aerugenosa ATCC 27853 and Escherichia coli ATCC 25922) as well as antifungal activity against Candida albicans ATCC 10231 and Aspergillus niger ATCC 106404 using the diffusion test on wells. We found that acetone extract exhibited significant antibacterial and antifungal activity against all strains used in contrast to the other extracts. The toxicity test of the acetone extract of our seaweed on the Artemia salina has shown that the DL50 is more than 1000 μg/mL which proves the non-toxicity of our extract.