Hepatoprotective Activity of “Orthosiphon stamineus” on Liver Damage Caused by Paracetamol in Rats

The objective of this study was to investigate the hepatoprotective activity of Methanol extract of leaves of Orthosiphon stamineus against paracetamol induced hepatotoxicity. The material was dried in shade, they were powdered and Extracted with methanol. Preliminary phytochemical tests were done. Methanol extract showed presence of phenolic compound and flavanoids. The hepatoprotective activity of the methanol extract was assessed in paracetamol induced hepatotoxic Rats.Alteration in the levels of biochemical markers of hepatic damage like SGOT, SGPT, ALP and lipid peroxides were tested in both Paracetamol treated and untreaed groups. Paracetamol (2g/kg) has enhanced the SGOT, SGPT, ALP and the Lipid peroxides in liver. Treatment of methanolic extract of O.Stamineus leaves (200mg/kg)has brought back the altered levels of biochemical markers to the near normal levels in the dose dependent manner.Our findings suggested that O.Stamineus methanol leaf extract possessed hepatoprotective activity.