Genetic Polymorphism of Manganese Superoxide Dismutase (MnSOD) Among Breast Cancer and Benign Breast Patients in Jordan: A Preliminary Study

This study investigated the association of MnSOD gene polymorphism with risk of both breast cancer and benign breast disorders among Jordanian females. MnSOD genotyping assay was conducted among 81 Jordanian participants including: 44 breast cancer patients, 19 benign breast patients and 18 healthy controls. In the breast cancer group, MnSOD allele frequency for Ala and Val alleles was 41% and 59%, respectively, which is similar to the Caucasian population. The most common MnSOD genotype among all study groups is Ala/Val genotype, while the Ala/Ala genotype was rare in benign breast patients and controls and was completely absent in breast cancer patients. Women with Ala/Val genotype were at highly significant increased risk for breast cancer (OR=10, 95% CI=2.51-39.83), while Val/Val genotype was correlated to a significantly decreased risk for breast cancer (OR=0.125, 95% CI=0.03-0.5). On the other hand, the similar risks for benign breast diseases were nonsignificant. Larger sample is needed to support that MnSOD polymorphism may be involved in breast cancer development and progression.