Toxic Effect of Dimethoate and Diazinon on the Biochemical and Hematological Parameters in Male Rabbits

Dimethoate and Diazinon are two of widely used organophosphorus insecticides in agriculture. The irrational use of Dimethoata and Diazinon in Yemen play a crucial role in the occurrence of many diseases affecting plants, animals and man. The present work was conducted to investigate the alterations in biochemical and hematological factors in male rabbits after orally administration a single dose of 1/4 LD50 of Dimethoate and Diazinon for 20 days. 30 Male Rabbits weighting 1500-1700g., were divided into 3 groups with 10 animals in each, first group served as control animals, they received 5 ml. of corn oil, while animals in second group received 1/4 LD50 of Dimethoate, animals in third group received 1/4 of LD50 of Diazinon .The concept of this study was to evaluate the hepatotoxic, and nephrotoxic effects of Dimethoate and Diazinon, therefore, the followings Biochemical parameters in serum were studied: aminotransferases (ALT and AST), alkaline phosphatase (ALP), total proteins, albumin, uric Acid, creatinin, and blood glucose. The followings hematological parameters were studied in blood: red blood cells (RBC), hemoglobin (Hb), and erythrocytes sedimentation rate (ESR).The Biochemical analysis showed that the levels of the ALT and AST as well as ALP, uric acid, creatinin, and blood glucose in the serum of treated rabbits significantly (P 0.01) increased compared to control animals, whereas either, total protein, and albumin, significantly decreased (P 0.01). Hematological factors were reduced in the treated groups