The effects of vitamin E and selenium on cisplatin‑induced nephrotoxicity in cancer patients treated with cisplatin‑based chemotherapy: A randomized, placebo‑controlled study

We read with great interest the article by Hemati and colleagues, entitled “The effects of vitamin E and selenium on cisplatin‑induced nephrotoxicity (CIN) in cancer patients treated with cisplatin (CP)‑based chemotherapy: A randomized, placebo‑controlled study,” published recently in your esteemed journal. They studied 22 patients, who received 400 IU vitamin E and 200 μg selenium daily and 24 patients received placebo. They found significant differences in glomerular filtration rate between the two groups after the third cycle and 1 month after the end of chemotherapy. They concluded that vitamin E and selenium can be used to reduce CIN. We congratulate the authors for their findings and their effort to find a way to reduce CIN.