Author/Authors :
Caterina, Palleria University of Catanzaro - School of Medicine - Department of Health Science, Italy , Antonello, Di Paolo University of Pisa - Department of Clinical and Experimental Medicine, Division of Pharmacology, Italy , Chiara, Giofrè University of Catanzaro - School of Medicine - Department of Health Science, Italy , Chiara, Caglioti University of Catanzaro - School of Medicine - Department of Health Science, Italy , Giacomo, Leuzzi Azienda Sanitaria Provinciale Catanzaro - Department of Primary Care, Italy , Antonio, Siniscalchi Cosenza Hospital - Department of Neurology, Italy , Giovambattista, De Sarro University of Catanzaro - School of Medicine - Department of Health Science, Italy , Luca, Gallelli University of Catanzaro - School of Medicine - Department of Health Science, Italy
Abstract :
Drug‑drug interactions (DDIs) are one of the commonest causes of medication error in developed countries, particularly in the elderly due to poly‑therapy, with a prevalence of 20‑40%. In particular, poly‑therapy increases the complexity of therapeutic management and thereby the risk of clinically important DDIs, which can both induce the development of adverse drug reactions or reduce the clinical efficacy. DDIs can be classify into two main groups: pharmacokinetic and pharmacodynamic. In this review, using Medline, PubMed, Embase, Cochrane library and Reference lists we searched articles published until June 30 2012, and we described the mechanism of pharmacokinetic DDIs focusing the interest on their clinical implications.
Keywords :
Absorption , adverse drug reaction , distribution , drug‑drug interactions , excretion , metabolism , poly‑therapy
