Title of article
Synthesis and Biological Evaluation of New 1,4-Thiazine Containing Heterocyclic Compounds
Author/Authors
Gupta, Shikha University of Rajasthan - Department of Chemistry, India , Ajmera, Neha University of Rajasthan - Department of Chemistry, India , Meena, Priyadarshi University of Rajasthan - Department of Zoology, India , Gautam, Naveen L.B.S. Govt. P.G. College, India , Kumar, Ashok University of Rajasthan - Department of Zoology, India , Gautam, D.C. University of Rajasthan - Department of Chemistry, India
From page
209
To page
221
Abstract
4H-1,4-benzothiazines are prepared by condensation of 2-aminobenzenethiol with β-diketones / β-ketoesters in dimethyl sulfoxide. These prepared benzothiazines are used as base to prepare ribofuranosides by treating them with β-D-ribofuranosyl-1-acetate-2,3,5-tribenzoate. 4H-1,4-benzothiazines, on refluxing with hydrogen peroxide in glacial acetic acid gave 4H-1,4- benzothiazine-1,1-dioxides (sulfones). Their antioxidant and antimicrobial activity have also been evaluated. Structure of the synthesized compounds have been established by their spectral investigation.
Keywords
4H , 1,4 , benzothiazines , Ribofuranosides , Antioxidant activity , Antimicrobial activity
Journal title
Jordan Journal of Chemistry
Journal title
Jordan Journal of Chemistry
Record number
2585046
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