Author/Authors :
Al-Gharabli, Samer German-Jordanian University - School of Applied Medical Sciences - Chemical-Pharmaceutical Engineering Department, Jordan , Al-Rifai, Nafisah German-Jordanian University - School of Applied Medical Sciences - Chemical-Pharmaceutical Engineering Department, Jordan , Saadeh, Haythem A. The University of Jordan - Faculty of Science - Department of Chemistry, Jordan , Mosleh, Ibrahim M. The University of Jordan - Faculty of Science - Department of Biological Sciences, Jordan , Mubarak, Mohammad S. The University of Jordan - Faculty of Science - Department of Chemistry, Jordan
Abstract :
A number of peptidyl metronidazole derivatives were synthesized in 99% yield through solid phase peptide synthesis. The newly prepared compounds were tested against Entamoeba histolytica and Giardia intestinalis and were found to be much less active than metronidazole against the aforementioned parasites; apparently the introduction of the peptide moiety on the metronidazole nucleus has an adverse effect on their antiparasitic activities. Nevertheless, grafting metronidazole with amino acids opens the window for parallel screening and combinatorial approaches.
Keywords :
Metronidazole , Peptides , Solid phase synthesis , Biological Activity
