Alterations in Lipid Peroxidation and some Trace Elements Concentrations in Sera and Tissues Homogenates of Women with Benign and Malignant Cervix and Uterine Tumors

The levels of sera and tissues homogenates malondialdehyde MDA (one of the lipid peroxidation products), was measured by Hirayama et.al spectrophotometry method, and the sera concentrations of some trace elements: Copper (cu), Iron (Fe), and Zinc (Zn) were evaluated in patients with benign cervix (n=28), malignant cervix (n=20), benign uterine tumors (n=33), and malignant uterine tumors (n=28),as measured by using flame atomic absorption spectrophotometer. A significant increase (P 0.05) in MDA concentration were found in sera of all above mentioned groups when compared with that of control group. However there were a high significant increase (P 0.005) in sera of pre-menopausal groups of patients with benign, malignant cervix and uterine tumors among the other groups. Tissues homogenates MDA levels showed significant increase (P 0.05) in case of cervix pre-malignancy (n=10), cervix (n=20) and uterus cancer (n=28) groups when compared with that of the other groups (n=68). The results indicated a significant decrease (P 0.05) in sera (Zn) concentration and a significant increase (P 0.05) in both sera (Cu) and (Fe) concentration in uterus and cervix cancer groups when compared with that of the other groups.