Title of article :
Synthesis of Some New Chalcone and 4,5-Dihydro-1H-Pyrazole Derivatives as Potential Antimicrobial Agents
Author/Authors :
Ibrahim, Mohammad M. University of Al al-Bayt - Faculty of Science - Department of Chemistry, Jordan , Al-Refai, Mahmoud University of Al al-Bayt - Faculty of Science - Department of Chemistry, Jordan , Abu-El-Halawa, Rajab University of Al al-Bayt - Faculty of Science - Department of Chemistry, Jordan , Tashtoush, Hasan University of Al al-Bayt - Faculty of Science - Department of Chemistry, Jordan , Alsohaili, Sohail University of Al al-Bayt - Faculty of Science - Department of Biology, Jordan , Masad, Mohanad University of Al al-Bayt - Water, Environment and Arid Regions Research Centre, Jordan
Abstract :
Condensation of 3-acetyl-2,5-dichlorothiophene with 1- or 2-naphthaldehyde led to theformation of the new chalcones (3a,b) in high yields. The latter chalcones were used as a backbone for the synthesis of substituted 3-(2,5-dichlorothiophen-3-yl)-4,5-dihydro-5-(naphthalen-1 or 2-yl)-1H-pyrazole (4a-h) in good yields. All newly synthesized compounds were characterized by standard spectroscopic techniques. The microbiological activity of these new compounds was investigated against bacteria and fungi. The new compounds showed good to excellent activity against all microbial species used for screening.
Keywords :
Chalcone , Pyrazole , 3 , Acetyl , 2,5 , dichlorothiophene , Antimicrobial , Condensation.
Journal title :
Jordan Journal of Chemistry
Journal title :
Jordan Journal of Chemistry
