Title of article
Synthesis of Some New Chalcone and 4,5-Dihydro-1H-Pyrazole Derivatives as Potential Antimicrobial Agents
Author/Authors
Ibrahim, Mohammad M. University of Al al-Bayt - Faculty of Science - Department of Chemistry, Jordan , Al-Refai, Mahmoud University of Al al-Bayt - Faculty of Science - Department of Chemistry, Jordan , Abu-El-Halawa, Rajab University of Al al-Bayt - Faculty of Science - Department of Chemistry, Jordan , Tashtoush, Hasan University of Al al-Bayt - Faculty of Science - Department of Chemistry, Jordan , Alsohaili, Sohail University of Al al-Bayt - Faculty of Science - Department of Biology, Jordan , Masad, Mohanad University of Al al-Bayt - Water, Environment and Arid Regions Research Centre, Jordan
From page
115
To page
123
Abstract
Condensation of 3-acetyl-2,5-dichlorothiophene with 1- or 2-naphthaldehyde led to theformation of the new chalcones (3a,b) in high yields. The latter chalcones were used as a backbone for the synthesis of substituted 3-(2,5-dichlorothiophen-3-yl)-4,5-dihydro-5-(naphthalen-1 or 2-yl)-1H-pyrazole (4a-h) in good yields. All newly synthesized compounds were characterized by standard spectroscopic techniques. The microbiological activity of these new compounds was investigated against bacteria and fungi. The new compounds showed good to excellent activity against all microbial species used for screening.
Keywords
Chalcone , Pyrazole , 3 , Acetyl , 2,5 , dichlorothiophene , Antimicrobial , Condensation.
Journal title
Jordan Journal of Chemistry
Journal title
Jordan Journal of Chemistry
Record number
2585241
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