Title of article :
One-Pot Synthesis of 2-Alkyl/arylamino-6-chlorothieno[3,2-e]-1,3-thiazin-4-one
Author/Authors :
Abu-El-Halawa, Rajab University of Al al-Bayt - Department of Chemistry, Jordan , Abu-El-Halawa, Rajab Albaha University - Clinical Pharmaceutical College, Saudi Arabia , Haj Elhussin, Imad Elddin Al al-Bayt University - Chemistry Department, Jordan , Al-Refai, Mahmoud University of Al al-Bayt - Department of Chemistry, Jordan , Ibrahim, Mohammad University of Al al-Bayt - Department of Chemistry, Jordan
Abstract :
2-Alkyl/arylamino-6-chlorothieno[3,2-e]-1,3-thiazin-3-one derivatives were prepared in one-pot synthesis by refluxing alky/arylisothiocyanates and 2,5-dichloro-3-thiophenecarboxamide. Alternatively, these derivatives were prepared by the intramolecular cyclization of the deprotonated 2,5-dichloro-N-(alkyl/arylaminocarbonothioyl)thiophene-3-carboxamides, which were obtained by the reaction of the deprotonated 2,5-dichloro-3-thiophene-carboxamide with alky/arylisothiocyanates. The structures of the newly synthesized bicyclic derivatives, and their acyclic precursors, were confirmed based on microanalytical and spectral (IR, MS, and NMR) data.
Keywords :
Thieno[3,2 , e] , 1,3 , thiazin , 3 , one , thiophene , 3 , carboxamides , isothiocyanates , intramolecular cyclization
Journal title :
Jordan Journal of Chemistry
Journal title :
Jordan Journal of Chemistry
