Title of article
Efficient Three-Component Synthesis of 3,4-Disubstituted Isoxazol-5(4H)-ones in Green Media
Author/Authors
Kiyani, Hamzeh damghan university - School of Chemistry, دامغان, ايران , Jabbari, Morteza damghan university - School of Chemistry, دامغان, ايران , Mosallanezhad, Asiyeh damghan university - School of Chemistry, دامغان, ايران
From page
279
To page
288
Abstract
Several derivatives of 3,4-disubstituted isoxazol-5(4H)-ones were synthesized via a onepot, three-component cyclocondensation reaction of hydroxylamine hydrochloride, various aryl aldehydes and β-oxoesters. The process takes place in water at room temperature. Tetrabutylammonium perchlorate (TBAP), sodium oxalate or glycine act as catalysts in promoting this reaction. The merits of this method are its efficiency, simplicity, cleanness, greenness, easy work-up, high chemical yields, recyclability, avoidance of using organic solvents, as well as the relatively short reaction times.
Keywords
Isoxazol , 5(4H) , one , Catalyst , Green chemistry , Three , component synthesis
Journal title
Jordan Journal of Chemistry
Journal title
Jordan Journal of Chemistry
Record number
2585338
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