Title of article :
Efficient Three-Component Synthesis of 3,4-Disubstituted Isoxazol-5(4H)-ones in Green Media
Author/Authors :
Kiyani, Hamzeh damghan university - School of Chemistry, دامغان, ايران , Jabbari, Morteza damghan university - School of Chemistry, دامغان, ايران , Mosallanezhad, Asiyeh damghan university - School of Chemistry, دامغان, ايران
Abstract :
Several derivatives of 3,4-disubstituted isoxazol-5(4H)-ones were synthesized via a onepot, three-component cyclocondensation reaction of hydroxylamine hydrochloride, various aryl aldehydes and β-oxoesters. The process takes place in water at room temperature. Tetrabutylammonium perchlorate (TBAP), sodium oxalate or glycine act as catalysts in promoting this reaction. The merits of this method are its efficiency, simplicity, cleanness, greenness, easy work-up, high chemical yields, recyclability, avoidance of using organic solvents, as well as the relatively short reaction times.
Keywords :
Isoxazol , 5(4H) , one , Catalyst , Green chemistry , Three , component synthesis
Journal title :
Jordan Journal of Chemistry
Journal title :
Jordan Journal of Chemistry
