Measurement of Serum 17 -ßEstradiol Levels Related to Age and Some Related Biochemical Parameters in Postmenopausal Women with Vertebral Osteoporotic Fracture

Osteoporosis (OP) is a systemic skeletal disease of compromised bone strength leading to increase bone fragility and a consequential increased risk of fracture. It is possibly estrogen and aged related in postmenopausal women . The present study investigated the role of 17/ß-Estradiol hormone, body mass index (BMI), age and bone related parameters like calcium, phosphate and alkaline phosphates in postmenopausal women with vertebral osteoporotic fracture and compared their levels with postmenopausal women without vertebral osteoporotic fracture and their contribution to the pathogenesis of osteoporosis. Methodes: This study was performed during December 2010 to March 2011. Subjects were selected from Outpatients who were attended to Osteoporosis Clinic in Al- Yarmouk Teaching Hospital. Eighty postmenopausal osteoporosis women were included in this study with age range 50-77 years. Menopausal status was defined by the absence of menses for more than 1 year in a woman 50 years of age and over. Subjects were allocated into two groups: group A: 44 were women with vertebral fractures (serve as patients) and group B: 36 women without vertebral fracture (serve as controls). Lateral X- ray of the thoracic and lumbar spine were taken for all women of both groups which scored according to semi quantitative evaluation of vertebral deformation (Kleerekoper method).All women were diagnosed as osteoporosis with DXA (GE machine/lunar DPX -NT version 13.60). All women have no history of severe trauma or falling to the back. Results: Estrogen estimation revealed a very high significant decline in the serum level of 17ß-Estradiol in 44 patients (groupA)(63.18±13.70pmol/l) range 48.4-80.9pmol/L when compared with 36 controls (group B) (75.63±34.64pmol/l) range 111.2-50.8 pmol/L (p=0.0001) .There is a significant difference in mean value of age between patients (62.77±7.40 years) range 50-77 years and controls(58.92±4.84 years) range 50-67 years (p-0.009) .Data regarding bone related parameters like serum levels of calcium, phosphorus and bone formation marker alkaline phoaphatase as well as body mass index(BMI) showed no significant differences for all patients and controls. Conclusion: Findings of this study predected that osteoporosis incidence increased with aging and described that aging and hormonal changes together are important factors contributing to the increased development of bone loss and osteoporosis. Decreasing in serum 17/ß-Estradiol levels in osteoporosis postmenopausal women provide evidence that determining their serum levels can be used as reliable markers in diagnosis of vertebral osteoporotic fractures or osteoporosis and also play an important role in pathogenesis of osteoporosis.