Author/Authors :
Yang, Hua the Third People’s Hospital of Liaocheng - Department of Neurology, China , Xu, Jian-Xin Taishan Medical University - Liaocheng People’s Hospital and Liaocheng Clinical School - Department of Neurology, China , Kong, Xiang-Zhi the Third People’s Hospital of Liaocheng - Department of Neurology, China , Ren, Zeng-Guang the Third People’s Hospital of Liaocheng - Department of Neurology, China , Xia, Zhang-Yong Taishan Medical University - Liaocheng People’s Hospital and Liaocheng Clinical School - Department of Neurology, China , Qu, Huai-Qian Taishan Medical University - Liaocheng People’s Hospital and Liaocheng Clinical School - Department of Neurology, China , Wang, Le-Xin Taishan Medical University - Liaocheng People’s Hospital and Liaocheng Clinical School - Department of Cardiology, China
Abstract :
Objective: This study was designed to investigate the relation between plasma von Willebrand factor (VWF) or endothelin-1 (ET-1) and post-carotid artery stenting (CAS) restenosis. Materials andMethods: Plasma levels of VWF and ET-1 were measured in 61 patients (36 males, mean age 64.4 ± 6.8 years) before and after CAS. The mean follow-up time was 13.8 ± 1.7 months (range, 6–63). In-stent restenosis was defined as a 10% narrowing of the vascular lumen with or without ischemic symptoms following CAS. Results: In-stent restenosis was identified in 14 (23%) patients, including 3 with 50% restenosis. In the restenosis group, mean VWF and ET-1 levels at 2 weeks, 1 and 6 months after CAS were higher than the baseline levels (p 0.05 or p 0.01). Mean levels of VWF and ET-1 in the restenosis group were higher than in the non-restenosis group within 6 months after CAS (p 0.05 or p 0.01). Conclusion: Persistent elevation in plasma VWF and ET-1 within the first 6 months of CAS was found in patients with in-stent restenosis.
Keywords :
Carotid artery stenosis , Stenting , Von Willebrand factor , Endothelin , 1 , Stroke
