Author/Authors :
Türkoğlu, Recai Istanbul University - Institute for Experimental Medicine (DETAE), Haydarpasa Numune Education and Research Hospital - Department of Neurology, Turkey , Gencer, Mehmet Istanbul University - Institute for Experimental Medicine (DETAE), Haydarpasa Numune Education and Research Hospital - Department of Neurology, Turkey , Ekmekçi, Duygu Istanbul University - Institute for Experimental Medicine (DETAE), Haydarpasa Numune Education and Research Hospital - Department of Neurology, Turkey , Ulusoy, Canan Istanbul University - Institute for Experimental Medicine (DETAE), Haydarpasa Numune Education and Research Hospital - Department of Neuroscience, Turkey , Erdağ, Ece Istanbul University - Institute for Experimental Medicine (DETAE), Haydarpasa Numune Education and Research Hospital - Department of Neuroscience, Turkey , Şehitoğlu, Elçin Istanbul University - Institute for Experimental Medicine (DETAE), Haydarpasa Numune Education and Research Hospital - Department of Genetics, Turkey , Çavuş, Filiz Istanbul University - Institute for Experimental Medicine (DETAE), Haydarpasa Numune Education and Research Hospital - Department of Genetics, Turkey , Haytural, Hazal Istanbul University - Institute for Experimental Medicine (DETAE), Haydarpasa Numune Education and Research Hospital - Department of Neuroscience, Turkey , Küçükerden, Melike Istanbul University - Institute for Experimental Medicine (DETAE), Haydarpasa Numune Education and Research Hospital - Department of Neuroscience, Turkey , Yalçınkaya, Nazlı Istanbul University - Institute for Experimental Medicine (DETAE), Haydarpasa Numune Education and Research Hospital - Departments of Neuroscience, Turkey , Turan, Selin Istanbul University - Institute for Experimental Medicine (DETAE), Haydarpasa Numune Education and Research Hospital - Department of Neuroscience, Turkey , Akbaş-Demir, Deniz Istanbul University - Institute for Experimental Medicine (DETAE), Haydarpasa Numune Education and Research Hospital - Department of Neurology, Turkey , Çoban, Arzu Istanbul University - Institute for Experimental Medicine (DETAE), Haydarpasa Numune Education and Research Hospital - Departments of Neuroscience, Turkey , Vural, Burçak Istanbul University - Institute for Experimental Medicine (DETAE), Haydarpasa Numune Education and Research Hospital - Department of Genetics, Turkey , Tüzün, Erdem Istanbul University - Institute for Experimental Medicine (DETAE), Haydarpasa Numune Education and Research Hospital - Departments of Neuroscience, Turkey
Abstract :
Objective: This study was conducted to identify a biomarker for multiple sclerosis (MS) that can be used as a predictor of relapse and disability. Materials and Methods: Sera of 26 consecutive relapsing-remitting MS (RRMS) patients were screened for switch-associated protein 70 (SWAP-70) antibody, which was previously identified by protein macroarray. The serum levels of several cytokines, chemokines and soluble adhesion molecules related to MS attacks were measured by enzyme-linked immunosorbent assay (ELISA). A possible correlation was sought among levels of SWAP-70 antibody, measured humoral factors and disability scores. Results: ELISA studies showed high-titre SWAP-70 antibodies in 16 (61.5%) RRMS sera obtained during the attack period and 9 (34.6%) sera obtained during remission. There was a significant inverse correlation between SWAP-70 antibody levels and expanded disability status scale scores, CXCL10, soluble VCAM-1, CXCL13 and soluble VLA-4 levels. Conclu- sion: Our results showed that SWAP-70 antibodies could potentially be utilized as relapse and prognostic biomarkers in MS. Whether or not SWAP-70 antibodies have any effect on disease mechanisms requires further investigation.
