Author/Authors :
Alver, Ahmet Karadeniz Technical University - Faculty of Medicine, Vocational School of Health Sciences, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital - Department of Medical Biochemistry, Turkey , Menteşe, Ahmet Karadeniz Technical University - Faculty of Medicine, Vocational School of Health Sciences, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital - Department of Medical Biochemistry, Program of Medical Laboratory Techniques, Turkey , Menteşe, Ümit Karadeniz Technical University - Faculty of Medicine, Vocational School of Health Sciences, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital - Department of Cardiovascular Surgery, Turkey , Sümer, Ayşegül Karadeniz Technical University - Faculty of Medicine, Vocational School of Health Sciences, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital - Department of Medical Biochemistry, Turkey , Uçar, Fahri Karadeniz Technical University - Faculty of Medicine, Vocational School of Health Sciences, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital - Department of Medical Biology and Genetics, Turkey , Altay, Diler Us Karadeniz Technical University - Faculty of Medicine, Vocational School of Health Sciences, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital - Department of Medical Biochemistry, Turkey
Abstract :
Objective: The aim of this study was to investigate the presence of anti-carbonic anhydrase (CA II) autoantibodies in patients with end-stage renal disease (ESRD) and relationships between the autoantibody titers and ghrelin, glucose, blood urea nitrogen (BUN) and creatinine. Subjects and Methods: Serum CA II autoantibody titers, malondialdehyde (MDA), BUN, creatinine and ghrelin levels were measured in 45 ESRD patients and 45 healthy subjects. Results: The CA II autoantibody titers in the ESRD group (0.170 ± 0.237) were significantly higher than those in the control group (0.079 ± 0.032; p = 0.035). MDA and ghrelin levels were also significantly higher in the ESRD group (p 0.001). A weak positive correlation was determined between anti-CA II antibody titers and MDA, and a negative correlation was observed between ghrelin levels and anti-CA II antibody titers (r = 0.287, p = 0.028 and r = –0.278, p = 0.032, respectively). Conclusions: In ESRD patients, the results showed the development of an autoimmune response against CA II. This suggests that anti- CA II antibodies could be involved in the pathogenesis of ESRD.
