One-pot Synthesis, Characterization and Antimicrobial Activity of New 3-Cyano-4-alkyl-6-(2,5-dichlorothiophen-3-yl)-2(1H)-pyridones

The one-pot synthesis of new derivatives of 2(1H)-pyridone heterocycles carrying a thiophene nucleus is described. The reactions were carried out via the condensation of 3-acetyl-2,5-dichlorothiophene and different alkyl aldehydes 2a-f with ethyl cyanoacetate in presence of ammonium acetate. The pyridone derivatives 3a-f were obtained in 63-86% yields and short reaction times. The antimicrobial activities of the new compounds were evaluated against some common Gram negative and Gram positive bacteria and fungi.