Title of article :
Synthesis, Characterization and Evaluation of Antiinflammatory Activity of Some 1-(2,4-Dinitrophenyl) - 3-Aryl-7-(Substituted Benzylidene)-2,3,4,5,6,7-Hexahydro-1H-Indazoles
Author/Authors :
Surur, Abdrrahman S. University of Gondar - School of Pharmacy, College of Medical and Health Sciences - Department of Pharmaceutical Chemistry, Ethiopia , Mekonnen, Yenus T. University of Gondar - School of Pharmacy, College of Medical and Health Sciences - Department of Pharmaceutical Chemistry, Ethiopia , Kumarachari, Rajasekhar K. University of Gondar - School of Pharmacy, College of Medical and Health Sciences - Department of Pharmaceutical Chemistry, Ethiopia , Kumar, Gollapinni Y. Sri Padmavathi School of Pharmacy - Department of Pharmaceutical Chemistry, India , Triveni, Singirisetty Raghavendra Institute of Pharmaceutical Education and Research (RIPER) - Department of Pharmaceutical Chemistry, India
Abstract :
The present work includes the synthesis of a series of new 1-(2,4-dinitrophenyl)-3-aryl-7- (substituted benzylidene)-2,3,4,5,6,7-hexahydro-1H-indazoles from substituted chalcones. These chalcones were prepared by the Claisen-Schmidt reaction of condensation of cyclohexanone with various substituted aromatic aldehydes. The synthesized compounds were confirmed by IR, 1H NMR and MASS spectral analysis. The synthesized compounds were screened for anti-inflammatory activity by the gelatin zymography method. The synthesized compounds having unsubstituted phenyl ring at 3rd and 7th positions exhibited maximum activity.
Keywords :
Indazoles , MMP , 2 and MMP , 9 Inhibitory activity , Gelatin zymography
Journal title :
Jordan Journal of Chemistry
Journal title :
Jordan Journal of Chemistry
