Clinical Course of Ventricular Septal Defect in Children Referred to Aliasghar Center of Zahedan during 2001-2011

Objective: The aim of this study is a review of clinical progress of ventricular septal defect in children referred to Aliasghar Center of Zahedan during 2001 to 2011. Method: In this research we have studied all files existing in the archive of the patients referred to Aliasghar Diseases Center of Zahedan, from 2001 to September 2011. The cases with ventricular septal defect diagnosed by echocardiography were selected and required data including location and size of VSD, patient’s age along with the manner of VSD closure (spontaneously, surgery, intervention) were collected. Results: Among 1750 patients with congenital heart diseases, 621 cases (35.5%) were suffering from VSD. In 32.3% of cases, the defect was closed spontaneously, 12.7% underwent closed heart operation, and 53% received medical therapy. Based on the defect location, there were 11.9% muscular, 72.8% perimembranous, 8.1% outlet, and 7.2% inlet type. Also the size of the defect in patients with isolated VSD was as follows: 45.1% small type, 25.9% moderate type, 29% large type. In general, serious complications have been occurred in 4.34% of the patients in long term follow up. Conclusions: In this study, it has been indicated that the incidence of spontaneously closure of small defects has been increased with time and a large number of moderate defects convert to minor defects by time and few number of large defects spontaneously closed by time. The incidence of serious complications in long term was 4.34% and mostly the results were similar to the results of other studies in this regard.