Antibiotic Consumption and Development of Resistance among Gram-Negative Bacilli in Hospitalized Patients of King Abdullah University Hospital (KAUH) in North Jordan

This prospective study was carried out to investigate the incidence of resistance in Gram-negative bacilli against an injectable form of third generation cephalosprins (Ceftriaxone) and an injectable form of aminoglycosides (Amikacin) in relation to several antibiotics used in King Abdullah University Hospital (KAUH). Pseudomonas aeruginosa were most frequently isolated from blood, respiratory tract and wound specimens. Enterobacter spp were most frequently isolated from blood specimens. E. coli was the most frequent isolate from urine. Ceftriaxone was most frequently used against E. coli (19.6%), while Amikacin was most frequently used against P. aeruginosa (19.1%). The rate of resistance of E. coli for ceftriaxone was 20%, and for amikacin was 40%. For Amikacin, 22.2% of P. aeruginosa cases and 33.7% of Acinetobacter spp cases were resistant. In conclusion, through analysis of the rates of resistance in KAUH / Jordan, we found that it s worthy to conduct a multicenter / national study studying the incidence of bacterial resistance in Jordan