Title of article :
Mega-dose Vitamin C: Is it Harmful to the Liver? Biochemical and Histological Study in Rats
Author/Authors :
Abdul-Razzak, Khalid Jordan University of Science and Technology - Faculty of Pharmacy, Jordan , Yacoub, Mohammed Jordan University of Science and Technology - Faculty of Medicine, Jordan , Hananeh, Wael Jordan University of Science and Technology - Faculty of Veterinary Medicine, Jordan , Arif, Shayma’a Jordan University of Science and Technology - Faculty of Medicine, Jordan
Abstract :
Aim: To investigate if mega-doses of vitamin C would have deleterious effects on the liver in an animal model.Methods: A mega-dose of vitamin C (1000 mg/kg/day) was administered by oral gavage to male Wistar rats for60 days. Both biochemical and histopathological measures were undertaken.Results: The results showed that a mega-dose of vitamin C significantly elevated lipid peroxidation andtransaminase activity level in addition to the significant suppression of antioxidant enzymes activities. Theseresults were consistent with the presence of histological lesions.Conclusion: A mega-dose of vitamin C is not safe and can cause liver injury
Keywords :
Mega , dose , vitamin C , liver lesions
Journal title :
Jordan Journal of Pharmaceutical Sciences
Journal title :
Jordan Journal of Pharmaceutical Sciences
