Title of article
Mega-dose Vitamin C: Is it Harmful to the Liver? Biochemical and Histological Study in Rats
Author/Authors
Abdul-Razzak, Khalid Jordan University of Science and Technology - Faculty of Pharmacy, Jordan , Yacoub, Mohammed Jordan University of Science and Technology - Faculty of Medicine, Jordan , Hananeh, Wael Jordan University of Science and Technology - Faculty of Veterinary Medicine, Jordan , Arif, Shayma’a Jordan University of Science and Technology - Faculty of Medicine, Jordan
From page
8
To page
20
Abstract
Aim: To investigate if mega-doses of vitamin C would have deleterious effects on the liver in an animal model.Methods: A mega-dose of vitamin C (1000 mg/kg/day) was administered by oral gavage to male Wistar rats for60 days. Both biochemical and histopathological measures were undertaken.Results: The results showed that a mega-dose of vitamin C significantly elevated lipid peroxidation andtransaminase activity level in addition to the significant suppression of antioxidant enzymes activities. Theseresults were consistent with the presence of histological lesions.Conclusion: A mega-dose of vitamin C is not safe and can cause liver injury
Keywords
Mega , dose , vitamin C , liver lesions
Journal title
Jordan Journal of Pharmaceutical Sciences
Journal title
Jordan Journal of Pharmaceutical Sciences
Record number
2587107
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